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KMID : 0378019710140010095
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New Medical Journal
1971 Volume.14 No. 1 p.95 ~ p.100
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Effect of ｒ-Aminobutyric Acid on the Intestinal Motility of Rabbit Exposed to Chronic Hypoxia
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Abstract
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It has long been recognized that GABA have an initial inhibitory effect on the heart and intestine of Crustacea and Mammalia. But the effect -of GABA on the hypoxic -intestine is not known. In order ´to find ,lout -the effect of GABA on the intestinal motility of rabbits exposed to chronic hypoxia,´ the present experiments were performed on albino rabbits of both sexes, weighing approximately 2 kg using Magnus method and the animals divided into three groups, the control, chronic hypoxia and recovery group. Control group was normal, a group of chronic hypoxia rabbit was exposed 8 hours a day to simulated altitude of 18000 feet-25000 feet for a period of 10 weeks, and recovery group was past 10 days after 10 weeks exposure to the chronic hypoxia.
The results were summarized as follows:
1. The RBC count and hemoglobin concentration increased due to the exposure to chronic hypoxia. These changes returned to normal progressively after withdrawal of exposure to hypoxia.
2. GABA inhibited the intestinal movement of normal rabbit.
3. GABA had no effect or rather increased the contractility of intestinal movement of rabbit exposed to chronic hypoxia.
4. The initial inhibitory action of GABA on intestinal motility was weakened in the rabbit of recovery group compared to control group.
5. Above results suggest that the period of 10 days was not sufficient to recover from chronic hypoxia.
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